Paolo (Vincenzo Amato), an Italian who drives a Paris tour bus, has just proposed to his true love, the German stewardess, Greta (Nora Tschirner), when the young French beauty, Cécile (Louise Monot) pulls up beside his bus on her bicycle - and, in short order, Paolo, following some very bad advice from his friend, Derek (Paddy Considine), finds himself with a German fiancée, a French "wife", two Australian children who call him "Papa", and his life upside-down.

In Los Angeles, the eleven year old Anna Fitzgerald seeks the successful lawyer Campbell Alexander trying to hire him to earn medical emancipation from her mother Sara that wants Anna to donate her kidney to her sister. She tells the lawyer the story of her family after the discovery that her older sister Kate has had leukemia; how she was conceived by in vitro fertilization to become a donor; and the medical procedures she has been submitted since she was five years old to donate to her sister. Campbell accepts to work pro bono and the obsessed Sara decides to go to court to force Anna to help her sister.

A down-and-out golfer attempts to recover his game and his life with help from a mystical caddy.